If you have extremely dry skin, you may find that niacinamide is better than azelaic acid due to its ability to support the skin's natural protective barrier (and thus, encourage . So, if you want to use this combination, I strongly advise you should start from lower concentration for the sake of your skins moisture-barrier, (example: 0.05% tretinoin and 10% azelaic acid). However if youre a new acid-user and want to give these two actives a shot, please do well to contact your board-certified dermatologist first (for advice whether or not to use them). Niacinamide can help to reduce the irritation associated with retinol use, while retinol can help to exfoliate, smooth skin and reduce texture, acne and signs of aging. A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquidinto a nice gel formula. Heres What To Know. Khi phi hp hai hot cht ny vi nhau va an ton li cho hiu qu r rt. In this experimental review, I used tretinoin 0.1% gel and azelaic acid 20% gel every-other-day for three (3) weeks, at night-time only. Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. . Here you'll find science-based skincare advice that gets results. Retinoic acid irritates the skin and causes the cells of the skin to grow (divide) and die . Also its very important to start from a low concentration, especially if you have a sensitive skin. When it comes to tretinoin, you can bend this rule a little and use a moisturizer before tretinoin, which can help buffer the active ingredients and reduce any potential irritation or other side effects. It usually comesto the formula as part of athickener-emulsifier trio paired withPolyisobutene andPolysorbate 20. Courtesy of brand The Ordinary Niacinamide . I ordered the Niacinamide, azelaic acid, and vitamin C serums, and have been applying the C first followed by Niacinamide and azelaic acid mixed together. The short answer is yes, you can use tretinoin and niacinamide together! A 6 month study involving 289 people found that 20% Azelaic Acid cream and 0.05% Tretinoin were "equally effective" against acne. All Rights Reserved. Copyright 2019 - 2023 BeautySparkReview. Its an effective ingredient to treat acne, hyperpigmentation, and premature aging. Retinoids can work to promote healthy skin cells, while azelaic acid can reduce inflammation and prevent irritation and breakouts caused by the retinoid. Naturium Azelaic Acid Emulsion 10% Plus Bioactive Brightening Complex & Niacinamide, Aging Skin Treatment, 1 oz. It also reduces free fatty acid production, part of the pathogenesis of acne . A typeof ceramidethat can be found naturally in the upper layer of the skin. As cosmetic chemist kindofstephenwrites on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". Thats a lie, sometimes it does. By blocking the production of unwanted pigmentation, it also helps . Many of the acne-fighting effects of tretinoin also improve signs of aging, but its ability to promote collagen production helps create that "glow" in aging skinas well as improve other signs of aging. I skip the vitamin C in the morning but use the mix both morning and night. Chances are youve heard of both tretinoin and niacinamide both of which have become insanely popular in recent years for their skin benefits. It reduces inflammation and diminishes the . Other benefits of the compound may include the reduction of fine lines and wrinkles and the lessening of hyperpigmentation. In the study of comedonal acne, 20% azelaic acid cream was equally effective as 0.05% tretinoin cream in reducing the number of comedones and with respect to overall response. While niacinamide comes in many different forms: cleansers, toners, serums, etc., tretinoin just comes in a gel or cream form, which makes it a little bit easier! From my experimental review with the usage of tretinoin and azelaic acid together, I have come to the conclusion that both acids are effective individually, but more effective when combined together in treating acne breakouts (especially cystic and hormonal acne) and improving skin texture and complexion. You can separate the two products in your routine, depending on your preferences. Thanks to inflammation soothing properties, azelaic acid can be an excellent option for people looking to treat acne and rosacea. Also-called: All-Trans-Retinoic Acid, Form of Retinoids | What-it-does: cell-communicating ingredient. Retinoid is the name for the family of chemicals. Helpful. Background: Acne is an inflammatory disorder with a high global burden. It normalizes keratinization and makes the pores produce less sebum. This method is called the sandwich technique. As you might guess from the pro part, its a precursor to vitamin B5 (whose fancy name is pantothenic acid). Has to be combined with other preservatives. It's one of the important lipids that can be found naturally in the outer layer of the skin. Btw, it's also used as a food preservative. It contains niacinamide, or vitamin B3, which has been shown to reverse sun damage and even out pigment. NAD and NADP are key components of many essential metabolic pathways in the human body. . With tretinoin helping to combat pigmentation to uneven skin tone and azelaic acid helping rid the skin of dead skin cells often which tends to make dark spots appear darker. So apply whichever product is thinner first, followed by the thicker product. Then you'll love to like our Facebook There is emerging research about Phytosphingosine that shows that it has antimicrobial and cell-communicating properties and is considered part of the skin's natural defense system. The most common skincare ingredient of all. A randomised investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne. Yes azelaic acid can be used in the morning and tretinoin cream at night, however, a common side effect of both medications is dryness, irritation, peeling, etc. Tretinoin works to smooth the skin's texture while azelaic acid works to exfoliate dead skin cells and fight bacteria. You can use tretinoin and niacinamide together without any issues or worries of irritation. Good old water, aka H2O. After using these duo-actives every-other-day for three (3) weeks, at night time only, Ive come to share my honest experience with these acids, but before I plunge into that, lets know what these ingredients are and what they do for the skin. I apply only a pea-size amount of both actives on my skin. is drying. Can Tretinoin And Azelaic Acid Be Used Together? Side effects: It's one of the gentlest skin-lighteners available . Tretinoin cream available in 0.025%, 0.05%, 0.1% strengths with niacinamide 4%. But you can safely mix them together if you prefer to use both tretinoin and niacinamide at the same time. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. 6 Possible Reasons, Is Panoxyl Good For Acne? It's believed that ceramide 1 plays a "binding role" in the lipid layers of the extracellular matrix. Common formulations prepared at Galleria Medical Pharmacy include but are not limited to: Tretinoin 0.015% / Azelaic Acid 4% / Niacinamide 4% Cream, Tretinoin 0.03% / Azelaic Acid 4% / Niacinamide 4% Cream, Tretinoin 0.045% / Azelaic Acid 4% / Niacinamide 4% Cream. Tiny-winy (micron sized) spheres that store emollient safflower seed oil and vitamin E. Oleosomes are both natural emulsifiers and time-released delivery systems that give the skin long-lasting moisture. Combining tretinoin, azelaic acid, and niacinamide into one formulation may increase patient compliance with treatment and improve both conditions. I used Azelaic Acid (Finacea) after pregnancy to help clear melasma and was happy with it, but I was breastfeeding at . I also have been doing at-home glycolic peels (30% by Instanatural, but I've just bought a 50% from another brand . Vitamin C or Ascorbic acid brightens the skin tone and also reduces the signs of aging. The preparation is applied to the affected area once to twice daily and the ingredients work synergistically together to decrease redness and pimples. Azelaic acid is well known to be a hater of acne, it kills acne causing bacteria(P. acnes) and cleanses the pores of pore-clogging impurities, all thanks to its mild exfoliating potentials. N Engl J Med 1997;337:1419-28. Also included was a small moisturizer and cleanser. A helper ingredient that helps to makethe products stay nice longer, aka preservative. I dont use them everyday (but every-other-day) and also i hydrate and moisturize my skin before layering the actives. With a rsum like that, its no wonder that this ingredient has been growing a steady following in skincare! A: While using tretinoin and azelaic acid together, I had no irritation, this is because I played smart. Yoham AL, Casadesus D, Tretinoin. Oh, and one more thing: alkaline pH inhibits enzymes that help ceramide synthesis in our skin. Retinoids and hyaluronic acid or niacinamide work deep into the dermis to treat acne and reduce signs of aging. Were here to tell you what we know, but dont take it as medical advice. (Moisturize, tretinoin & azelaic acid, moisturize again). New skin cells lead to your skin looking brighter and more even. Here's an example of how to use tretinoin and niacinamide together. The ingredients. For example, if youre using a niacinamide serum and a tretinoin cream, use the niacinamide serum first, followed by the tretinoin cream. I have done a month of 0.025 and just started 0.05, using daily. Step 3: Apply tretinoin cream all over your face. Where can I find these skincare ingredients. In this experimental review, I used tretinoin and azelaic acid every-other-day, for three (3) weeks, at night-time only. Available: https://go.drugbank.com/drugs/DB00548. 3. 57 64, 2004. A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. Ingredients explained. Get that glow! A handy white powder that magically converts a liquid into a nice gel formula. This one is the so-called esterified version. Those treatments include topical depigmenting agents, such as hydroquinone, tretinoin, azelaic acid, superficial peels and lasers. According to Joshua Zeichner, MD, director of cosmetic and clinical research at Mount Sinai Hospital, Unlike other acids, azelaic acid does not make you sensitive to the sun.. Azelaic Acid 10% Plus Niacinamide & Hyaluronic Acid Facial Serum, Dark Spot Remover and Wrinkle Reducer, Rosacea Skin Care - 1oz. A helper ingredient that's used as a co-emulsifier (meaning next to other emulsifiers in the formula it helps water and oil to mix) and as a stabilization agent for foams. Skincare: Humectant toner every day before tretinoin. Nhng c bit l Azelaic Acid li du nh v t tc dng ph. I do all the research for you and pick out the best products and advice to get you the skin of your dreams. Along with ceramides 4 and 7, they also play a vital role in epidermal integrity and serve as the main storage areas for linoleic acid (a fatty acid that's alsovery important for barrier repair). Tretinoin speeds this up and gives dead, damaged skin cells the boot.. Store this medication at 68F to 77F (20C to 25C) and away from heat, moisture and light. Its pH dependent and works best at acidic pH levels (3-5). Niacinamide and azelaic acid can be used together without any negative side effects. This is to enable me give a precise review about the combination of these two acids. Altreno (tretinoin lotion) package insert; Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2018 Aug. Renova 0.02% (tretinoin cream) package insert; Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2013 Jun. Well, Ive been a long-time acid-user, (even though I have a sensitive skin), I technically know my way around acids and how to properly use them to avoid inflammatory-irritation. Azelaic acid is a safe and proven acne treatment: In two studies, 20% azelaic acid cream was shown to be more effective than 0.05% tretinoin cream and better tolerated. It also stimulates collagen and production. Retinol is a bit milder than its prescription counterparts and is often considered to be less effective, but thats not necessarily a bad thing! A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it. It is also produced naturally by a certain fungus found on human skin. Fluocinolone, hydroquinone, and tretinoin topical may also be used for purposes not listed in this medication . However, if you must use them, endeavor to follow the technique I used, by using the buffer or sandwich method, and using every-other-day (resist the urge of applying these acids daily) for the sake of your moisture-barrier. Tretinoin "Tretinoin is a potent prescription retinoid derived from vitamin A, which can improve the hyperpigmentation . And they are there in big amounts! Xem thm: Review tr mn Tretinoin Gel USP 0.05 Obagi. Its truly a do-it-all ingredient! Well, we shall know about that. Its a humectant meaning that it can help the skin to attract water and then hold onto it. Read full disclosure here. We wrote way more about ceramides at ceramide 1, so click here to know more. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated. Apply a thick layer of occlusive cream over the treatment. Tretinoin usually comes in 3 strengths 0.025% mildest-strength, 0.05% medium-strength and 0.1% strongest-strength. By combining azelaic acid's anti-inflammatory properties with retinoids' cellular benefits, patients may be able to reach an equilibrium in their skin care plan. So apply whichever product is thinner first, followed by the thicker product. Copyright 2021 Galleria Medical Pharmacy. It also helps to disperse insoluble particles (think color pigments or zinc/titanium dioxide sunscreen) nice and even in cosmetic formulas. Just sign up or start a chat with your provider to get started! page. Its the - sodium form - cousin of the famous NMF,hyaluronic acid(HA). Talk to your medical provider about your specific health concerns. Word of advice, stick to using this potent cocktail in your evening skincare routine as both ingredients increase the photosensitivity of the skin. Niacinamide is a form of Vitamin B3 that offers many benefits for the skin, which is why its become one of the most popular skincare ingredients in the last couple years. While mild cases of acne may respond well to over-the-counter treatments, stubborn cases require stronger treatments. If the product is too runny, a little xanthan gum will make it more gel-like. Azelaic Acid v Niacinamide. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. Azelaic acid is a mild, . Combined with polyacrylate-13 and polysorbate 20, it forms a very effective tickener-emulsifier trio. A polymer (big molecule from repeated subunits) that's used as a gloss improver for lipsticks and lipglosses. Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) A film forming polymer that usually comesto the formula as part of athickener-emulsifier trio paired withPolyisobutene andPolysorbate 20. Can You Use Niacinamide With Azelaic Acid? No alcohol or fragrance either. In my own case, i had some ugly-looking minor acne breakouts. We have written way more about ceramides at ceramide 1, so click here to know more. All acne breakouts wiped-off without a trace. . You can see for yourself in the pictures below: And what actually baffled me was that, the result was rapid, I swear I could see my acne gradually healing at day-3 of treatment. It's one of the most commonly used thickeners and emulsion stabilizers. Monday-Friday: 9am-5pm Azelaic acid sounds technical, so you might be surprised to learn that it's a naturally occurring substance found in grains like wheat and barley. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. Its stickiness also helps lip products to stay on longer. This concentration is as effective at 4% hydroquinone (but a lot gentler!).. The creams contain a mixture of ingredients, such as tretinoin, niacinamide, and azelaic acid. For every script written, Skin Medicinals donates a portion of proceeds to non-profits . PC Chiu, CC Chan , HM Lin, HC Chiu, The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial, Journal of Cosmetic Dermatology vol.6, issue 4, pp. A natural corn sugar derived glycol. Azelaic acid is one of the most popular picks for hyperpigmentation in patients of all skin typesand for good reason. Its anti-inflammatory properties are also beneficial in treating redness. Plus, it acts as a mild exfoliant; it helps with skin texture and with smoothing and refining the appearance of pores. After clearing the way, tretinoin welcomes in fresh, plump skin cells and gives them the support they need by stimulating the production of collagen: a protein that helps with skin firmness. This, in turn, helps reduce the appearance of fine lines and wrinkles. Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. However, it can also be one of the most irritating, which is why its prescription only. This is because, azelaic acid (being a mild acid and exfoliant) can tend to cause skin-irritation when applied on moist skin as a result of increased absorption. Apply a thin layer to the targeted areas of the skin once a day. Thanks. A: If youre an individual with super-senstive skin, and wish to go for retinol instead of tretinoin (which is the most potent of all retinoids), then youre definitely on the right track. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. . Available from: https://www.ncbi.nlm.nih.gov/books/NBK557478/. Azelaic acid occurs naturally in some whole grains, but its generally safe to use topically for those with celiac disease or gluten sensitivities. Both niacinamide and azelaic acid reduce redness and inflammation, help brighten skin and fade hyperpigmentation. Niacinamide, azelaic acid, and Vitamin C are wonderful actives and have a host of skin benefits when approached correctly. Some of these ingredients are ones that your Curology provider can potentially prescribe to you. Azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and rye. It belongs to a class of molecules known as retinoids, which is an umbrella term for all Vitamin A compounds and derivatives like retinol or adapalene. You can start from 0.025 or 0.05% tretinoin and 5 or 10% azelaic acid to ease your way into these acids and to allow your skin gradually build tolerance or get accustomed to them. . The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. 137 144, March 2017. In this study, the researcher established that tranexamic acid . Has antimicrobial and cell-communicating properties and is considered to be part of the skin's natural defence system. But still endeavor to maintain the every-other-day application technique and not everyday. . But before we go into the details, let's just quickly define what the heck ceramides are: They are waxy lipids that can be found naturally in the outer layer of the skin (called stratum corneum - SC). Retinoids + vitamin C. may cause over-exfoliation . Base Ingredients: Caprylic/capric triglycerides . The Ordinary Natural Moisturizing Factors + HA, You can read my experimental-comparison review between The Ordinary & Paulas Choice azelaic acid 10%, I Used Niacinamide & Lactic Acid Together Heres My Review, I Used Niacinamide And Azelaic Acid From The Ordinary Brand & This Happened, Skin Purging Or Breaking Out? In healthy skin, skin cells naturally turn over, meaning that your old cells die and new ones replace them. Can You Use Niacinamide With Hyaluronic Acid? In fact, the niacinamide can actually help to reduce the irritation from the tretinoin! As a general rule, youll want to follow the thinnest to thickest rule. In general, oleosomesare tiny-winy (micron sized) spheres that store emollient plant oils (+ some other things). No wonder, it is a very popular and common ingredient. Tretinoin is a medication used to treat acne and sun-damaged skin. I definitely think the azelaic acid is what saved me from a bad purge too, such a great . What Happens When You Stop Using Tretinoin, Is Castor Oil Comedogenic? Azelaic acid is a multifunctional skincare ingredient that tackles a multitude of concerns related to breakouts and inflammation: Gently exfoliates: It goes deep within the pores and removes dead skin cells that cause dull skin tone and clogged pores. Spreading wasn't a huge issue. Your dermatology provider prescribes your formula . Tretinoin + Niacinamide = A Dream Team for acne, scarring, pigmentation and aging. An error has occurred. Dont forget to start from lower concentration and build your way up (if need be). Dermatica Tretinoin, Niacinamide 4%, Azelaic Acid 4%. It is also difficult to find a single product that is effective in treating both acne vulgaris and rosacea. A prescription from a medical provider (like your Curology provider!). Tretinoin TAN Mild Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.03/4/4% 30 mL Pump Tretinoin TAN Strong Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.045/4/4% 30 mL Pump General Information Tretinoin. Use just twice a week to begin with and increase slowly. This makes them helpful in the treatment of both acne and aging skin! NADH, as a reduction agent, reduce the alcohol group to aldehydes. Usually the main solvent in cosmetic products. But that shouldnt mean you should not always wear your sunscreen, for Christs sake do wear yoursunscreenalways (during the day) before stepping outside. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. For a new user trying to ease into Tretinoin, especially for those with sensitive skin, it's best to use it no more than twice the first week. This vitamin C serum contains 2% retinol and 3.5% niacinamide, as well as hyaluronic acid and salicylic acid. It's also a skin lightener though not as effective as gold-standard hydroquinone. Irvine, CA: Allergan Inc.; 2003, Jun. Since its not as strong, retinol can be found in some over-the-counter products, whereas you can only get tretinoin with a prescription from a medical provider. Azelaic acid acts as a chemical exfoliator unblocking pores, facilitating . They both have antioxidant, anti-inflammatory, and antibacterial properties but, unlike niacinamide, azelaic acid also acts as a mild exfoliant. But before we go into the details, let's just quickly define what the heck ceramides are: So, the answer is Yes, you can definitely use azelaic acid and retinol together and still achieve same result (but not as effective as the combination of tretinoin and azelaic acid together). If youre wondering should you use niacinamide or tretinoin first, keep on reading. Warning: This ingredient list belongs to a topical product regulated as medicine and uses different ingredient listing rules than regular cosmetics. It is common in adolescents and primarily affects sebaceous gland-rich areas. It can't erase deep wrinkles, but it can help improve the appearance of surface wrinkles, fine lines . A polymer (big molecule from repeated subunits) that's used as a gloss improver for lipsticks and lipglosses. This is temporary, but uncomfortable nonetheless. Using azelaic acid and niacinamide together is generally well-tolerated by most skin types, which is why they are often used in tandem in product formulations. Similar to tretinoin and retinol, azelaic acid puts a stop to future outbreaks as it kills acne-causing bacteria and clean bacteria from your pores that causes acne. Tretinoin; Est Retail. ingredients Tretinoin 0.05% + Niacinamide 4% + Azelaic acid 4% . It works on the skin cell level and makes your skin cells behave in a healthy and normal way. A preservative that works mainly against fungi. Pathophysiology of premature skin aging induced by ultraviolet light. It can be used to improve skin moisturization, as a solvent, to boost preservative efficacyor to influence the sensory properties of the end formula. Similar to niacinamide, azelaic acid is a multi-functional skincare ingredient, as it tackles different kinds of skin issues and fix imperfections such as acne, rosacea, redness, hyperpigmentation, melasma and shrink large pores. In rarer cases, swelling, rashes, hives, and difficulty breathing have been reported. According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, its also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. A typeof ceramidethat can be found naturally in the upper layer of the skin. Tretinoin is a proven powerhouse for reducing fine lines and unwanted pigmentation (second only to sun protection). It's because there are lots of different ceramides, a 2014article writes that currently 12 base classes of ceramides are known with over 340 specific species. When you buy a product via our links, we may earn a small commission,, Table of Contents What Is hyperpigmentation?What causes hyperpigmentation?What are types of hyperpigmentation?How is hyperpigmentation diagnosed?How is hyperpigmentation treated?How. I'm so glad you're here! In particular, Safflower Oleosomes are created from safflower seeds and carrysafflower seed oil and vitamin E. According to the manufacturer, oleosomes work both as natural emulsifiers as well as time-released delivery systems. So far we were writing about ceramides in plural. Azelaic Acid is effective during all stages of acne 1: it reduces active acne, it helps clear up the redness, scarring, and hyperpigmentation that acne can cause, and it keeps acne bacteria at bay once your skin has healed. I love 0.05% tretinoin. You can as well be a Beautysparker by joining our Facebook group, for discussions on skincare. While using these duo-actives, my skin was not only acne-free, but super-smooth, firm and plump. Curology (Active: 0.25% Zinc Pyrithione, 4% Niacinamide, 4% Azelaic Acid // Inactive: Water, glycerin, aloe vera leaf juice, PEG-100 myristate, sweet almond seed oil, xanthan gum, methyl paraben, propyl paraben, tocopheryl acetate.) Please try again later! Theres also some evidence that suggests topical niacinamide may decrease sebum, or oilso if youre concerned about excess oil on some parts of your face, this might be a great ingredient to explore! Niacinamide is a gentle ingredient that is suitable for all skin types, even those with sensitive skin. Tretinoin - A perscription-strength retinoid that's often used to treat acne and reduce the appeafance of wrinkles.. Niacinamide - A form of vitamin B3 that reduces inflammation, brightens the skin and helps repair the skin barrier.. Azelaic acid - A naturally-occurring acid that's obtained from grains and cereals. I recommend consulting with your dermatologist regarding any further questions and concerns. Avoid anything irritating while your skin is getting used to tretinoin- no scrubs, benzoyl peroxide, vitamin C, glycolic acid or salicylic acid. The tretinoin order is important when using this ingredient in your skincare routine. If youre wondering should you use niacinamide or tretinoin first, the answer will depend on your products! As aforementioned, Im not new to acids, I know my way around acids. Azelaic acid is an anti-keratinizing agent that prevents the buildup of dead skin cells, which can cause congestion. Tr nm da hiu qu nh kt hp Azelaic Acid vi Tretinoin. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. Tretinoin, Niacinamide 4%, Azelaic Acid 4%, All-Trans-Retinoic Acid, Form of Retinoids. What seems to be a true difference, though, is that the salt form is more stable, easier to formulate andcheaper so it pops up more often on the ingredient lists. Azelaic acid is a skincare ingredient found in wheat and barley, with antibacterial and anti-inflammatory properties that help keep skin clear. Hyperpigmentation. Keep all medicine out of the reach of children. Alpha Arbutin with Niacinamide: Alpha Arbutin and niacinamide serum are both water-based lightweight serums that can blend quite well. And also endeavor to hydrate and moisturize with a lightweight moisturizer before applying/layering these acids (as to protect your moisture-barrier). With skincare trends constantly changing, theres one thing that will always be true: science. A redditor also attested to the efficacy of both acids.
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